Analysis of the Fitness Effect of Compensatory Mutations
2008) Analysis of the Fitness Effect of Compensatory Mutations. Technical Report TR-08-01, Computer Science, Virginia Tech. (
We extend our previous work on the ﬁtness effect of the ﬁxation of deleterious mutations on a population by incorporating the effect of compensatory mutations. Compensatory mutations are important in the sense that they make the deleterious mutations less deleterious, thus reducing the genetic load of the population. The essential phenomenon underlying compensatory mutations is the nonindependence of mutations in biological systems. Therefore, it is an important phenomenon that cannot be ignored when considering the ﬁxation and ﬁtness effect of deleterious mutations. Since having compensatory mutations essentially changes the distributional shapes of deleterious mutations, we can consider the effect of compensatory mutations by comparing two distributions where one distribution reﬂects the reduced ﬁtness effects of deleterious mutations with the inﬂuence of compensatory mutations. We compare different distributions of deleterious mutations without compensatory mutations to those with compensatory mutations, and study the effect of population sizes, the shape of the distribution, and the mutation rates of the population on the total ﬁtness reduction of the population.
|Item Type:||Departmental Technical Report|
|Subjects:||Computer Science > Bioinformatics|
|Deposited By:||Administrator, Eprints|
|Deposited On:||14 November 2008|